Hair Loss - RonLev, why aren't you answering my questions?

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RonLev, why aren't you answering my questions? (Topicals)

posted by RonLev, 01.06.2008, 16:42
(edited by RonLev on 01.06.2008, 16:50)

» » » Jacob, can you think of any reason why such a thing as
» » » they describe there would enable topical flutamide
» » » to have a "local" effect?
» »
» » Yep.
»
» Good.
Bryan,

I don't think our recent exchanges have really changed my position or yours, so I haven't responded to some of these replies. My position, as I have stated, is that flutamide has shown a greater effectiveness (and a greater duration of effectiveness over several years of use, which is just as important) in regrowing and/or retaining hair, at the expense of some systemic absorption and consequently some side effects, which vary from one individual patient to another. Your focus on one (animal) study simply confirms that flutamide's effects can be systemic, they do not preclude that their effects can also be local, especially when doses are titrated--NO STUDY HAS BEEN PUBLISHED TO DENY OR CONFIRM THIS (and unfortunately most clinical practitioners have to depend on their empirical judgment, in the absence of studies that would resolve this question that pharma refuses to fund.) I don't think we need to belabor our differences in opinion. That is where my position stands, and it is not disputed by our dermatologic consultants. Naturally, I would like a "perfect" antiandrogen that has the effectiveness of flutamide but without any systemic effects, but we do not have such an agent yet. When you are presented with a patient in dispair over hairloss who does not respond well to lower-potency treatments, we need to offer a solution, albiet with fully disclosing to the patient that there are risks and benefits, as with any other treatment. Bryan, have you ever been faced with accepting or rejecting a treatment that your doctor considered justified after he duly advised you of possible side effects? This is a fact of life in every day clinical practice.

RonLev


RonLev is located in [NA] and he is available to meet: NO

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