Hair Loss - Four provisos for anyone interested in doing this

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Four provisos for anyone interested in doing this (Hair Multiplication & Research)

posted by bug2, 18.06.2008, 05:20

» I don't recommend taking lithium as an oral supplement for hair loss -- no
» evidence that it can help with hair loss. In fact, in high doses lithium
» carbonate can actually CAUSE hair loss. In lower doses it is considered
» safe by the medical establishment for the treatment of mood disorders,
» however.
»
» But like I said lithium actually has ANTI-cancer properties. Since most of
» us have MPB, which is strongly correlated with prostate cancer, here's an
» interesting article:
»
» Sun A, Shanmugam I, Song J, Terranova PF, Thrasher JB, Li B. Lithium
» suppresses cell proliferation by interrupting E2F-DNA interaction and
» subsequently reducing S-phase gene expression in prostate cancer.
» Prostate. 2007 Apr 17; [Epub ahead of print]
» PMID: 17440966 [PubMed - as supplied by publisher]
»
» "BACKGROUND: Lithium is an existing drug for bipolar disorder
» and its uptake was recently linked to reduced tumor incidence
» compared to the general population. The major target of lithium
» action is glycogen synthase kinase 3 (GSK-3). Since GSK-3
» expression and activation are associated with prostate cancer
» progression, the anti-cancer potential of lithium on prostate
» cancer was investigated in this study. METHODS: Multiple
» prostate cancer cell lines were treated with lithium chloride
» (LiCl). Cell proliferation and cell cycle distribution were
» analysed. DNA replication was determined using BrdU labeling
» assay. Genome-wide screening of gene expression was performed
» using cDNA microarray assay. GSK-3beta gene-specific silencing
» was conducted using small interferencing RNA (siRNA)
» transfection. E2 factor (E2F) transactivation was evaluated
» using reporter gene assay and E2F-DNA interaction was
» determined with chromatin-immunoprecipitation assay (ChIP).
» RESULTS: LiCl significantly inhibited cell proliferation, which
» was associated with reduced DNA replication and S-phase cell
» cycle arrest. LiCl significantly decreased the expression of
» multiple DNA replication-related genes, including cell division
» cycle 6 (cdc6), cyclin A, cyclin E, and cdc25C, which are
» regulated by E2F factor during cell cycle. A novel GSK-3-
» specific inhibitor TDZD-8 and GSK-3beta siRNA also suppressed
» the expression of these E2F target genes, indicating that LiCl-
» induced anti-cancer effect was associated with GSK-3beta
» inhibition. Furthermore, LiCl suppressed E2F transactivation by
» interrupting the interaction of E2F1 factor with its target
» gene promoter. CONCLUSIONS: These data indicated that LiCl
» suppresses cancer cell proliferation by disrupting E2F-DNA
» interaction and subsequent E2F-mediated gene expression in
» prostate cancer. Prostate (c) 2007 Wiley-Liss, Inc."
»
» Isn't it interesting how finasteride also limits the spread of prostate
» cancer?
»
» » BB wrote:
» »
» » -lithium appears very safe as a topical AND oral supplement-
» »
» » Please stay away from lithium!!!!
» » Lithium is used in the drug therapy of major depression. It is well
» known
» » for its very narrow therapeutic range and its strong side-effects. It
» » should not be used as an oral supplement.
» »
» » I don´t know about topical application but I would stay away from it as
» » well.
» »
» » Should be hard to get too...
very


bug2 is located in [NA] and he is available to meet: NO

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