Hair Loss - benji

hair loss products

Free Ads


shop
Forum News Hair Transplant Hair Replacement Topical All Natural Drugs Hair Multiplication Gallery Female Hair Loss

Hair Loss

Forum Index   Personal Journal   Poll

Log in | User | Register

Search:  
Back to forum
Board view

London Free Consultations Dec 15-19  |  Hair Transplant Patient Reviews
 

benji (Hair Multiplication & Research)

posted by Amilcar, 05.07.2008, 16:32

» Quote:
» The invention further features a kit including a composition formulated
» for topical administration including (i) a small molecule EGFR inhibitor
» selected from leflunomide, gefitinib, erlotinib, lapatinib, canertinib,
» vandetanib, CL-387785, PKI166, pelitinib, HKI-272, and HKI-357; and (ii)
» an additional biologically active agent selected from an antihistamine, an
» anti-inflammatory, a retinoid, an anti-androgen, an immunosuppressant, a
» channel opener, an antibiotic, and an antimicrobial.

whats the point of using an anti androgen ?

Do you think the antibiotic and antimicrobial are here only for safety reasons ?

In one embodiment,
» the small molecule EGFR inhibitor is gefitinib or erlotinib and the
» additional biologically active agent is a channel opener selected from
» minoxidil, diazoxide, and phenytoin.
»
»
»
»
»
»
»
» Time related stuff from the patent:
»
»
» Quote:
» for applying the composition to the skin of a subject once or twice daily,
» for applying the composition to the skin of a subject for at least 2, 3,
» 4, 5, 6, 7, 8, 9, or even 10 consecutive days, for administering the
» composition during the night, or administering the composition during the
» day. The invention features a method for generating a hair follicle or
» stimulating a hair growth on the skin of a subject by (i) disrupting the
» skin of the subject (for example, resulting in the induction of
» reepithelialization of the skin of the subject) and (ii) contacting the
» cells of the skin with a small molecule EGFR inhibitor, or a metabolite
» thereof, in an amount sufficient to generate hair follicles or
» stimulate hair growth on the skin. In certain embodiments, step (a) is
» performed less than two weeks, 10 days, 8 days, 5 days, or even 3 days
» prior to step (b). In other embodiments, step (a) is performed
» simultaneous with, or more than one day, two days, 3 days or one week after
» step (b).
»



Step (a) is (i) the disrupting and step(b) is (ii) the EGFR inhibition or what ?


»
»
»
»
»
»
» The very simpleist embodiment of the patent:
»
» Quote:
» In a particular embodiment of the methods, kits, and compositions of the
» invention, the EGFR inhibitor is administered, formulated,
» or is part of a kit with an anti-androgen (e.g., finasteride ) and a
» channel opener (e.g., minoxidil).
»
» In still another embodiment of the methods, kits, and compositions of the
» invention, the topical formulation is a cream, lotion, stick, ointment,
» gel, spray, foam, patch, aerosol, wound dressing, or drop.
»
»
»
»
»
»
»
» Quote:
» The disruption of the epidermis can be induced between 3-12 days
» (e.g., 4-12, 5-12, 4-11, 6-11, 6-10, 6-9, 7-8, 5-11, 5-10, or 7-10
» days) prior to the addition of the compositions of the invention.
»

ALL these are possible durations for the disrupting process with lower and higher bounds ?

» Any of the above-described methods may be used to remove a precise amount
» of epidermal tissue. For example, the methods of abrasion described herein
» may be used to achieve:
»
» • Removal of the stratum comeum through removal of the first 10-30
» μm of dead skin cells.
»

Could not read that level of disrupting in-depth ? how much ?

»
» I'd like to add an editorial note here..................3 days after
» wouding, or better yet 4, is likely when the skin will have
» re-epilithialized unless you took off more than the stratum cornelium in a
» human being. Hair germs were detected in human skin on the SCID mice at day
» 7. We heal quicker than mice do. So, on about day 4 or 5, one can probably
» feel reasonably safe to use the egf blocker and minox. One can be on finas
» for the entire time........
»

3 days or 4 through which you just do nothing ?

»
»
» Most important example in the patent:
»
» Quote:
» Example 7: EDIHN induces new hair follicles in human
» skin. Grafting. Discarded human adult scalp from the
» preauricular area obtained from plastic surgery was grafted onto
» immunodeficient (scid) mice. The graft was bandaged and allowed to heal,
» then was used in the wound healing study 3 months after grafting.
»

EDHN must stand for the whole process of disrupting+ EGFR yet I could not figure it out ? what does it stand for ?

» Results: To determine whether human skin responded to EDIHN as did mouse
» skin, human skin was grafted onto SCID (immuno-defϊcient) mice and
» subjected to depilation by plucking and wound induction three days later.
» Seven days following wound induction, formation of new HF was observed
» in the human skin (Figure 2 IA; arrows indicate new HF) by hematoxylin
» and eosin staining of paraffin embedded tissue sections.
THE last sentence about the hematoxylin..eosin to the end...Are t hey talking about the markers they used to show the new HFs ?

»
» In additional experiments, adult human skin was grafted onto mice,
» abraded, and examined at 7 days post-abrasion. New HF were generated in the
» human skin, which mimicked normal hair follicle formation during fetal
» development, as evidenced by staining for S100A6 or S100A4 (Figure 21B).
»

Dont they say for how long they did the abrasion in those experimentations ?
Also can you give the links for those figures !

» The results of this Example show that EDIHN can be used to generate
» hair growth in human skin as for mouse skin

Best regards.


Amilcar is located in [NA] and he is available to meet: NO

Post reply
 

Complete thread:

Back to forum
Board view
41637 Postings in 3835 Threads, 1682 registered users
Hair Loss | Admin contact
powered by MLF | FORUM POLICY

Dr. Klein: most comprehensive topical hair loss therapy
click here