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my experiment (Hair Multiplication & Research)

posted by haroldo, 10.07.2008, 02:59

» For the first eight days I ate an antibiotic (doxi..? dont remember) since
» I read in the patent that mice who fed on this for nine days grew pigmented
» hair. But they were geneticly altered so it may not have this effect on
» humans.

Yeah those mice are altered so as to express dkk1 in their skin after exposure to that particular antibiotic. Its a common sort of thing with GM (genetically modified) animals. The antibiotic acts as a promoter to express the gene.

» 48 hours after the wounding I started applying an immunosuppresant (Elidel
» cream) once a day for 9 days. I am not sure why immunosuppresant are in the
» patent but I figured that maybe it suppresed the Wnt signaling and caused
» pigmentation of the hair. Took a gamble on that one.

Interesting. I was curious as to how something in this class of drugs (tacrolimus, pimecrolimus, cyclosporine) would effect the process. On the one hand they seem to put stem cell proliferation into overdrive. On the other hand there is a paper that shows that at least some part of the immune response (macrophage recruitment) is necesaary for the stimulus of hair growth in response to wounding so I thought it might be unhelpful as well.


haroldo is located in [NA] and he is available to meet: NO


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