Hair Loss - ADERANS RESEARCH Launches Second Phase of Hair Loss Study - 27 Apr 2009
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ADERANS RESEARCH Launches Second Phase of Hair Loss Study - 27 Apr 2009 (Hair Loss Research & Clinical Trials)

posted by fckhrls, 02.05.2009, 20:59

» Due to technical issues with HM consistency, ARI's technique has a far
» greater chance of success than Gho's or ICX'. Gho was the early pioneer and
» actually used CD34+ stem cells from the patient's blood to fortify the
» nutrient mix and enhance the hair follicle stem cells ability to multiply
» and remain viable. But despite his brilliant pioneering idea, he could
» never develop a consistent protocol.
»
» Gho had done some early research into ICX' technique and abandoned it in
» favor of using hair follicle stem cells mixed with blood stem cell
» aggregates and kerotinocyte growth factors. Thus, unless ICX could figure
» out some new way to culture viable DP cells in 2-D suspensions, their
» research was bound to come up against (and did) similar consistency issues
» as Gho encountered.
»
» ARI has spent a great deal of time in the lab studying these issues and
» outcomes, and they're very familiar with the problems other researchers
» have encountered. Their emphasis is on 3-D environments using a multi-cell
» approach. IOW, they specialize in creating a self-contained environment
» that relies less on the patient's existing cells interacting with the
» injected cells. What separates this from previous companies' trials is this
» has never been tried before in humans. So it should prove to be quite
» exciting.
»
» ARI's approach is not a backyard approach. Kurt Stenn is a world-class
» hair follicle researcher and has assembled a team of researchers with
» impeccable credentials. ARI has taken its time in the lab (mostly because
» the issues are so difficult to solve), but I see this a good thing. The
» earlier attempts by other companies have been thwarted more than anything
» by lack of developing a consistent protocol prior to moving into human
» research. ARI's approach is different on many different levels and stands a
» high chance of commercial success. The amount of time and experiments they
» performed in the lab leading up to human trials is unprecedented. In many
» ways, this is the real deal this time. However, despite this, I expect the
» product will be clunky when it's first released (if it makes it that far).
»
» Phase II trials are typically 20-300 people, so ARI's effort can be
» thought of as a legitimate mid-level attempt (quite expensive). If they
» have success, most likely the phase III trials will be quite a bit bigger
» than phase II. Phase III trials typically involve 300-3000 people and cost
» an arm and a leg. So if we see a failure, it will most likely play out in
» phase II with a reluctance to continue funding.
»
» Technically ARI could finishes phase II in a year, enter and finish phase
» III in another year, and then submit the product for FDA review and get it
» on the shelf. However, that is not likely to happen. 2.5 years is possible,
» but "5 years" is more likely. LOL :)
Excellent post. Win, lose or draw, ARI's research should be very useful for future study.


fckhrls is located in [NA] and he is available to meet: NO

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