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It's very interesting... (Hair Loss Research & Clinical Trials)

posted by TAGOHL, 24.03.2012, 14:19

» But can someone confirm that CRTH2 is the same GPR44 receptor?
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11251

Official Symbol PTGDR2
Official Full Name prostaglandin D2 receptor 2
Primary source HGNC:4502
See related Ensembl:ENSG00000183134; HPRD:16075; MIM:604837; Vega:OTTHUMG00000167796
Gene type protein coding
RefSeq status REVIEWED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as DP2; DL1R; CD294; CRTH2; GPR44

Summary This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.
[provided by RefSeq, Mar 2011]




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