May 02 - May 08, 2005
Hair Multiplication – Curis’ New Treatment for Hair Loss Using Hedgehog Signaling.
”Hedgehog is one of many cell-signaling pathways that scientists are scrutinizing. And Curis hopes it will work wonders on thinning pates of both males and females. When you see a lustrous head of hair, chances are it's at least partly due to healthy Hedgehog signaling, which prompts the body's multitalented stem cells to proliferate around follicles, initiating hair growth. By activating Hedgehog, Curis' drug targets hair growth at its root, so to speak. That could make the drug more effective than current treatments, which mainly aim to increase the size of shrunken hair follicles or to fight certain hormones involved in hair loss.”
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May 02 - May 08, 2005
Hair Multiplication – Aderans Research Institute (ARI) recently reported their findings
on generation of mature cycling hair follicles from skin-derived cells. ARI scientists found that "...placement of 1 million trichogenic dermal cells (2:1 ratio of dermal to epidermal cells) will result in about 200 hair follicles. This translates into the estimate of 5000 dermal cells and 2500 epidermal cells per newly formed follicle..."
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May 02 - May 08, 2005
Hair Multiplication – Isolagen’s Skin Cell Injections to Tackle Baldness
Isolagen’s fibroblast injections may hold the key to baldness treatment. "Scientists have even succeeded in growing hair using these fibroblasts - cells which generate and control levels of the protein collagen and elastin and are found in skin, bones and other connective body tissue."
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Apr 04 - Apr 10, 2005
Hair Multiplication – InterCytex’s Critical Proprietary Step
Are we to assume Intercytex has now overcome the DP cell-related hair cycling problems of the past previously attempted by other researchers?
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Apr 04 - Apr 10, 2005
Hair Multiplication – Hair Multiplication – InterCytex Completed Phase I Trial
Phase I clinical trials (safety) have been completed in seven volunteers at a single UK transplant centre. No safety issues have arisen and five out of the seven patients have shown increased hair numbers. Safety studies will be followed by a multi-centre Phase II clinical trial on patients with male pattern baldness. The Phase II trial is planned for the first half of 2006 and will be performed in both the UK and North America. A Phase III trial for both male pattern baldness and female diffuse alopecia will be conducted in 2007.
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Mar 07 - Mar 13, 2005
Hair Multiplication – Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia.
”Male pattern baldness is thought to be a polygenic disorder. Which is to say that there are likely several genes involved in the development of pattern baldness. In this brand new study, researches have identified a polymorphism in the ornithine decarboxylase gene that appears to be associated with MPB. This is one more piece of the puzzle.”
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Mar 07 - Mar 13, 2005
Hair Multiplication – Dr. Cooley on Hair Multiplication
Probably the best straightforward explanation of HM for laymen that we have seen on the net to date. Article by Dr. Cooley.
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Mar 07 - Mar 13, 2005
Hair Multiplication – Hair Multiplication – Dr. Cooley on Hair Multiplication
Probably the best straightforward explanation of HM for laymen that we have seen on the net to date. Article by Dr. Cooley.
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Feb 07 - Feb 13, 2005
Hair Multiplication – Dr. LU Zhongfa: “Histological Study of Reconstructed Hair Follicles”
New study by Dr. Lu Zhongfa concludes that Dermal Papilla Cells can induce hair follicle regeneration and sustain hair follicle growth in vivo and in vitro in mice.
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Jan 31 - Feb 06, 2005
Hair Multiplication – Dr. Costarelis “Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen”
secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen” New study by Dr. Costarelis supports the notion that keratinocytes can “dedifferentiate” to a stem cell state in response to wounding, perhaps related to signals from the stem cell niche. Finally, we also present evidence that quiescent bulge cells undergo apoptosis during follicle remodeling in catagen, indicating that a subpopulation of bulge cells is not permanent.
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Jan 31 - Feb 06, 2005
Hair Multiplication – UWBio’s Hair Multiplication Experiment Update
Another update from UWBio on his personal Hair Multiplication experiement: “I followed Gho's procedure and I have come to the conclusion that he was not capable of getting keratinocyte growth either. If you look at the photo's he includes in his slides and in his article then you can clearly see that the cells have not even spread out, they are just circular and not in groups indicating no spread and no proliferation. I gave up on Gho's procedure and followed a procedure for isolating skin keratinocytes, but with plucked hairs.”
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Jan 17 - Jan 23, 2005
Hair Multiplication – Interview with Dr. Lu Zhongfa of China.
Interview with an up and coming Hair Multiplication researcher from China.
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Jan 17 - Jan 23, 2005
Hair Multiplication – Interview with Dr. Lu Zhongfa of China.
An email from InterCytex to forum members regarding Trichocyte’s trial design.
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Jan 17 - Jan 23, 2005
Hair Multiplication – InterCytex Phase I Trial Design
An email from InterCytex to forum members regarding Trichocyte’s trial design.
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Jan 10 - Jan 16, 2005
Hair Multiplication - “Wnt Signaling through the ß-Catenin Pathway Is Sufficient to Maintain, but Not Restore, Anagen-Phase Characteristics of Dermal Papilla Cells “
Abstract from Investigative Journal of Dermatology “Dermal papilla cells of the hair follicle can be maintained in an active, hair-inducing state in vitro when cocultured with cells secreting Wnt3a. By inducing cultured dermal papilla cells to secrete Wnt themselves, we demonstrate that this activity is a direct effect of Wnt signaling to dermal papilla cells. We further demonstrate that the effects of Wnt3a are exerted through activation of the ß-catenin signal transduction pathway and do not require alternative Wnt transduction cascades. Once dermal papilla cells have lost hair-inducing properties in vitro, neither treatment with Wnt nor expression of a truncated and activating form of ß-catenin is sufficient to restore these properties to the cultured cells.”
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Jan 10 - Jan 16, 2005
Hair Multiplication – Farjo Medical Center’s Collaboration with InterCytex’s
Abstract from “Dermatology, Isssue #5” – “Working with Intercytex, a Manchester-based regenerative medicine company (with facilities in Boston, USA), we are seeking to restore lost hair by injecting cultured dermal papilla cells back into the scalps of the volunteers to induce the formation of functioning hair follicles to grow hair in significant numbers.”
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Jan 10 - Jan 16, 2005
Hair Multiplication – InterCytex’s Phase I Trial in Manchester, UK
A reply from InterCytex to one of our readers “We are currently conducting a Phase I clinical trial in Manchester, UK. The investigational product, Trichocyte, is still at an early stage of development and the trial itself is purely a safety study - actual hair growth is not expected nor is it being assessed. The trial is designed only to allow injections on a very small area of the head to show that the product is safe for human use. To date, no results are available.”
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Jan 10 - Jan 16, 2005
Hair Multiplication – Dr. Gho’s FM Procedure and the Bisection Thin Hair Study
A question has arose lately about how Gho can possible bisect the hairs in the scalp, since the thin-hair study showed that a microscope had to be used.
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Jan 03 - Jan 09, 2005
Hair Multiplication:  Uwbio Hair Multiplication Experiment. Uwbio, one of our forum members and a scientist himself, started his own Hair Multiplication experiment a few months ago.  He just posted his most recent update with photos showing the image of a plucked hair removed from the side of his head and incubated at 37 degrees C. for 3 days.  You can still see the outer root sheath and the inner root sheath as well as the hair shaft.
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