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Scarring Alopecia or sometimes referred to as Cicatricial
alopecia. It is a rare condition in which inflammation destroys the
hair follicles and leaves behind scar tissue in the affected areas. The
hair loss can be permanent. For some people, this disorder can happen
slowly and gradually, very hard to diagnose. For others, the symptoms
can be in the form of severe itching, burning, pain and can progress
rapidly. The inflammation that destroys the follicle is below the skin
surface and there is usually no "scar" seen on the scalp. Affected areas
of the scalp may show little signs of inflammation, or have redness,
scaling, increased or decreased pigmentation, pustules, or draining
sinuses. This type of alopecia or baldness can happen to both men and
women of all ages in any parts of the world.
This type of alopecia can be classified as primary or
secondary. In primary cicatricial alopecias, the hair follicle is
the target of the destructive inflammatory process and nothing else. In
secondary cicatricial alopecias, destruction of the hair follicle is
incidental to a non-follicle-directed process or external injury, such
as severe infections, burns, radiation, or tumors.
Primary cicatricial alopecias are further classified by the type of
inflammatory cells that destroy the hair follicle during the active
stage of the disease. The inflammation may predominantly involve
lymphocytes or neutrophils. Cicatricial alopecias that predominantly
involve lymphocytic inflammation include lichen planopilaris, frontal
fibrosing alopecia, chronic cutaneous lupus erythematosus, central
centrifugal alopecia, pseudopelade (Brocq), alopecia mucinosa, and
keratosis follicularis spinulosa decalvans. Cicatricial alopecias that
are due to predominantly neutrophilic inflammation include folliculitis
decalvans, tufted folliculitis, and dissecting cellulitis. Sometimes the
inflammation shifts from a predominantly neutrophilic process to a
lymphocytic process. Cicatricial alopecias with a mixed inflammatory
infiltrate include folliculitis keloidalis and erosive pustular
dermatosis.
The cause of the various cicatricial alopecias is not well understood.
The only known causes so far is inflammation directed at the hair
follicle level, usually the upper part of the follicle where the stem
cells and sebaceous gland (oil gland) are located. If the stem cells are
destroyed, and the sebaceous gland as well, there is then no possibility
for regeneration of the hair follicle. The hair loss will be permanent.
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