- A Natural Supplement formulated
by Dr. Razack for Healthy
is a food supplement composed of minerals, vitamins and herbs. Its
intended use is for hair health and maintenance. It can also be used for
treatment of benign prostatic hyperplasia (BPH), the swelling of the
prostate in middle-aged men. People who use Natrecia can also use Dr.
Razack's topical hair maintenance
product, Crinagen. The components of Natrecia are: (per tablet).
Saw Palmetto Berries Extract 400 mg; Beta Sitosterol 200 mg; Rye PollenExtract 100 mg; Pumpkin Seed Extract 100 mg; Lycopene 50 mg; Zinc 20 mg;Copper 1 mg; Vitamin B6 (pyridoxal-5-phosphate) 10 mg; Phosphorus (as phosphate) 100 mg; Calcium 125 mg
The new Natrecia is in the form of alarge tablet and it contains substantially more saw palmetto content. Some people find it difficult to swallow. However, chewing very easily crushes the tablet. If chewed, it has a bitter taste due to the zinc content. So, taking it with fruit juice or food is recommended. The tiny blue specks on and inside the tablets are the copper oxide. The small white lumps on some tablets are normal. This was a very difficult tablet to compress because of the large amount of saw palmetto it contains.
is a completely natural, vitamin, mineral, and herbal supplement
specifically developed for combating the effects of androgenic alopecia
(AP) (i.e., male-pattern baldness). Its formulation is based on a
significant body of research that firmly establishes the effect that
certain natural agents have in combating the effects of
dihydrotestosterone (DHT) in the treatment of benign prostatic
This essay begins with a detailed discussion of the prostate gland because prostatic disease has a similar hormonal etiology to androgenic alopecia (male pattern hair loss). Both conditions are caused, in part, by the male sex hormone dihydrotestosterone (DHT). Most importantly, both conditions are preventable.
prostate is a gland located beneath the urinary bladder in men. It is
responsible for the production of fluids involved in reproduction. When
men urinate, the urine that is stored in the bladder must travel through
a conduit, called the urethra, before it can exit the penis. The urethra
passes through the prostate after exiting the bladder. This is because
in addition to carrying urine, the urethra is also responsible for
carrying the reproductive fluids that are produced in the prostate. As a
consequence of its location, an enlarged prostate can contribute to
urinary flow obstruction as well as to bladder dysfunction by
"squeezing" on the urethra. This can result in the various
urinary symptoms associated with an enlarged prostate, such as frequent
urination during the day, frequent urination at night, dribbling, having
a weak urinary stream, urgency, and incomplete emptying of the bladder.
It can also result in the inability to urinate altogether.
The medical term for a non-cancerous enlarged prostate is benign prostatic hyperplasia. The somewhat similar term, benign prostatic hypertrophy, is commonly used. Again, this condition is thought to result, in part, from exposure to specific androgens, such as dihydrotestosterone. Autopsy results reveal that virtually all men who live past a certain age develop this condition. Individuals born with a deficiency in 5-alpha reductase, the enzyme that produces dihydrotestosterone, suffer neither hair loss nor prostatic disease. People who lack this enzyme are unable to produce the more potent form of testosterone, dihydrotestosterone. Again, dihydrotestosterone (DHT) is required for the development of both androgenic alopecia (male pattern hair loss) and prostatic disease (BPH).
are two basic treatment options for an enlarged prostate gland or benign
prostatic hyperplasia. These include medical (drugs) and surgical
therapy. When men with benign prostatic hyperplasia, a condition many
physicians believe to be caused by excess dihydrotestosterone, were
treated with oral or systemic finasteride (the generic name of Propecia
and Proscar), their enlarged prostate glands became smaller .
Unfortunately, this study also revealed that a small percentage of the
patients (less than 6%) receiving this drug also suffered from sexually
related side effects such as decreased sex drive and impotence .
Surgical therapy can also lead to sexually related side effects.
Recently, medical literature has provided increased support for the use of naturally occurring nutrients that prevent the progressive enlargement of the prostate gland (BPH). Some of these nutrients have even been shown to reduce the incidence of prostate cancer! The nutrients that combat the detrimental effects of DHT in the prostate can be utilized to combat the effects of DHT in hair loss. The following discussion outlines multiple DHT-fighting agents. Each of these agents is included in Natrecia.
is by far the most commonly recognized and discussed herb concerning the
prostate. Before we even begin its discussion, I highly recommend
reading the book entitled "Saw Palmetto: Nature's Prostate
Healer" by Ray Sahelian, M.D. This is a marvelous book that
discusses the prostate and how Saw palmetto and other natural nutrients
can prevent prostate disease (BPH).
palmetto is a plant (dwarf palm tree) native to the United States. It
has been used medicinally for over a century. Its first use was
described in the medical literature in the 1800s. Early literature
concerning Saw palmetto stated that it relieved symptoms ranging from
prostate enlargement in men to gynecological problems in women, such as
menstrual discomfort. It has even been described as a potential
Saw palmetto contains hundreds of different substances that can account for its beneficial effects. Saw palmetto is usually distributed as a crushed berry or as an extract. The extract form contains most of the substances found to be effective in treating benign prostatic enlargement. The extract form has been shown to be more potent than the dried berry form. The extract, then, is the form of choice.
are many articles in the medical literature that establish the efficacy
of Saw palmetto in treating benign prostatic hyperplasia. One of the
most recent and prestigious articles is "Saw Palmetto Extracts for
the Treatment of Benign Prostatic Hyperplasia: a Systematic Review"
by Timothy J. Wilt, MD, MPH et al. It appeared in The Journal of the
American Medical Association on November 11, 1998 . The study clearly
demonstrated that the use of Saw palmetto improved urinary tract
symptoms associated with benign prostatic hyperplasia. It also
demonstrated that Saw palmetto provided similar improvement in urinary
tract symptoms when compared to drugs such as finasteride. Saw palmetto
was associated with fewer side effects. Although the mean study duration
(the period of time that participants were using Saw palmetto) was 9
weeks, participants were noticing positive results in as little as 4
weeks. Finasteride users commonly saw relief of symptoms after three
next three paragraphs are a bit technical, but some readers may
appreciate the detail. Others may wish to skip ahead to the paragraph
that begins, “It is clear that….”
total of 18 randomized controlled trials involving 2939 men who met
inclusion criteria were analyzed. Treatment allocation concealment was
adequate in 9 studies (i.e., they were single-blind tests), whereas 16
studies were double-blinded. The average duration of the study was 9
weeks. In comparison to the men in the placebo control group, men
treated with the SP extract Serenoa repens (S. repens or Saw palmetto)
showed a measurable improvement in urinary tract symptoms. The weighted
average difference for patients treated with S. repens was -1.41 points
with a 95% confidence interval of L2.52, -0.301, compared to the control
group's weighted-mean difference of -0.76 with a 95% confidence interval
of [-1.22, -0.32]. This represents a relative weighted mean difference
of 46% (Here, a lower weighted-mean difference correlates with improved
urinary tract function). The patients themselves provided
self-improvement ratings in urinary tract symptoms that were highly
correlated with their quantitative evaluations.
with men receiving finasteride, men treated with S. repens showed
similar improvements in urinary tract scores. The main advantage of
treatment of BPH with S. repens over finasteride was apparent in the
decreased incidence of adverse side effects. For example, 4.9% of
patients treated with finasteride reported erectile dysfunction compared
with 1.1% of patients treated with S. repens. These percentages are
based on the Neyman-Pearson binary hypothesis test with power function
parameter P set to P<0.001. That is, the probability of a Type-II
error was fixed at 0.999. Here, a Type-II error refers to the
probability of accepting the null hypothesis H_0 (no urinary tract
improvement) when the alternative hypothesis H_1 (urinary tract
improvement) is actually true. The significance level for all randomized
trials was set at 0.05, thus indicating a probability of 0.05 of
rejecting H_0 when H_1 is true.
key points regarding these results are in order here. First, since all
the statistical studies are based on classical (or frequentist) methods,
all inferences derived from them are inherently indirect. That is, no
direct claims can be made regarding the probabilities of improved
urinary tract function. Rather, one can only infer the probabilities
that the treatment did not fail. This is by no means a fallacy, neither
on the part of the researchers nor on the methods of data acquisition,
but is an inherent aspect of frequentist analysis. To emphasize this
point further, consider the value of the mean-weighted difference for
patients treated with S. repens. The reported value was -1.41. Note that
this is not a true statistical estimate of this parameter. Rather, it is
a measured value that has a 95% probability of being contained in the
random interval [2.52,-0.30]. If one wished to make direct inferences
from the data, non-classical statistical analyses, such as those based
on Bayesian decision theory, should be employed . Another point worth
mentioning concerns the sensitivities of the tests. Since the studies
did not report the standard errors of the differences between the means
of S. repens and control, the authors assessed the sensitivity of the
tests by analyzing data for three different values of correlation
coefficients, namely (0.25, 0.50, 0.75). The work, then, reported
"no significant statistical difference in outcomes according to the
three correlation coefficients." As a result, the correlation
coefficient was arbitrarily set to 0.50. One could certainly argue that
this is a somewhat ad-hoc approach. To be more precise and more
objective, the correlation coefficient could have (and should have) been
estimated by a standard technique such as the method of maximum
likelihood  or via another point estimator such as the Bayesian
minimum mean square error (MMSE) estimator or even the Bayesian maximum
a-posteriori (MAP) estimator . This would certainly have altered the
calculated relative weighted mean difference from its reported value of
46%, but to what degree is unknown. Note that the relative weighted mean
difference of 46% was not actually reported in the JAMA article  but
rather was calculated by the current authors based on the results in
is clear that there was an improvement in patients given Saw palmetto
over the placebo-control group, and, moreover, the improved urinary
tract function paralleled that which was displayed by patients taking
finasteride. This study clearly demonstrated that the use of Saw
palmetto improved urinary tract symptoms associated with BPH, and that
its effects were in concert with the improvements achieved through the
use of finasteride. It was also shown that, compared to finasteride, Saw
palmetto administration produced a lower incidence of adverse side
effects. The mean duration of the study encompassed 9 weeks of Saw
palmetto administration. However,
many participants were reporting positive results in as little as 4
Saw palmetto and finasteride were found to be effective in the treatment
of benign prostatic hyperplasia (BPH). This study clearly establishes
the role of Saw palmetto in combating the effects of DHT. Note that Saw
palmetto was compared to 5 mg of finasteride in this study and that
Propecia contains only 1 mg of finasteride.
Side effects experienced with Saw palmetto are infrequent. One three-year study with 315 patients showed that 98% of the patient population had no significant side effects . The most common side effects experienced with Saw palmetto include nausea and mild headache. Since Saw palmetto is fat-soluble, it is better to take it with meals. It usually takes one to two hours to be absorbed.
(relating to Saw palmetto):
Gormley GJ, et al. The effect of finasteride in men with benign
prostatic hyperplasia. N Engl J Med;327:1185-1191,1992.
T.J. Wilt, A. Ishani, G. Stark, R. MacDonald, J. Lau, and C. Muirow. Saw
Palmetto extracts for treatment of benign prostatic hyperplasia.
J. O'Berger, Statistical Decision Theory and Bayesian Analysis, 2nd Ed.,
Springer Verlag Series in Statistics, Springer,1985.
PJ. Bickel and K.A. Doksum, Mathematical Statistics -- Basic Ideas and
Selected Topics, Prentice Hall, Englewood Cliffs, NJ, 1977.
A. O'Hagan, Kendall's Advanced Theory of Statistics, Volume 2B: Bayesian
Inference, Halsted Press, New York, 1994.
D. Authie and J. Cauquil. A multicenter study of the efficacy of
Permixon in daily practice. Pharmacol Clin; 5(56):3-13, 1987.
Reading: For the section above and all sections below, there is
excellent reading in this book: Sahelian, R.; Saw Palmetto: Nature's
Prostate Healer; New York; Kensington Publishing Company, 1998.
africanum is an evergreen tree indigenous to Africa. Extracts from its
bark have been shown to improve urinary tract symptoms associated with
benign prostatic hyperplasia . Another study showed that, in addition
to improving symptoms associated with BPH, this herb also improved
sexual behavior in men . Although its exact mechanism is unknown,
many researchers speculate that it may work by inhibiting growth factors
responsible for the increase in prostate size. Another theory is that
this herb may have anti-inflammatory activity in the prostate gland
(relating to Pygeum africanum):
Barlet A, et al. Efficacy of Pygeum africanum extract in the medical
therapy of urination disorders due to benign prostatic hyperplasia:
evaluation of objective and subjective parameters. A placebo-controlled
double-blind multicenter study. Wien Klin Wocheschr 102:667-673, 1990.
2. Carani C, et al. Urological and sexual evaluation in the treatment of benign prostatic disease using Pygeum Africanum at high doses. Arch Ital Urol Nefrol Androl 63:341-345, 1991.
is a plant-derived sterol found in Saw palmetto and Pygeum Africanum.
Studies have shown that the use of beta-sitosterol has improved urinary
tract symptoms associated with benign prostatic hyperplasia . In
addition, beta-sitosterol inhibits the proliferation of cancer cells in
(related to beta-sitosterol):
Berges RR, Windeler J, Trampisch HJ, Senge T. Randomized,
placebo-controlled, double blind clinical trials of beta-sitosterol in
patients with benign prostatic hyperplasia. Beta-sitosterol Study Group.
Lancet. 345: 1529-1532, 1995.
Awad AB, Chen YC, Fink CS, Hemmessey T. Beta-sitosterol inhibits HT-29
human colon cancer cell growth and alters membrane lipids. Anticancer
Res 16:2797-2804, 1996.
nettle (Urtica dioica) is another herb indigenous to the United States.
This herb has been utilized in Germany for treating both BPH and
rheumatoid arthritis. Stinging nettle has been studied in combination
with both Saw palmetto and Pygeum africanum in the treatment of BPH.
When used with Saw palmetto, improvement in prostate-related urinary
problems was documented . When combined with Pygeum africanum, this
herb diminished the symptoms of BPH. Researchers believe that this
herb's effectiveness is due to its affect on the delivery of hormones to
the prostate gland.
(related to stinging nettle):
Schneider HJ, Honold E, Masuhr T. Treatment of benign prostatic
hyperplasia: Results of a treatment of Sabal extract WS 1473 and Urtica
extract WS 1031 in urologic specialty practices. Fortschr Med 113:37-40,
pollen extract does not contain pollen or other allergens. Rye pollen
extract has been shown to be effective in the treatment of BPH [1,2].
Its action is to inhibit the growth of prostate cells . The substance
in rye pollen extract that inhibits the growth of prostate cells also
inhibits the growth of prostate cancer cells .
(related to rye pollen extract):
Yasumoto R, et al. Clinical evaluation of long-term treatment using
cernitin pollen extract in patients with benign prostatic hyperplasia.
Clin Ther 17:82-87, 1995.
Dutkiewiccz S. Usefulness of Cenilton in the treatment of benign
prostatic hyperplasia. Int Urol Nephrol 28:49-53, 1996.
Habib FK, et al. Identification of a prostate inhibitory substance in a
pollen extract. Prostate 26(3):133-139,1995.
Zhang X, et al. Isolation and characterization of a cyclic hydroxamic
acid from a pollen extract, which inhibits cancerous cell growth in
vitro. J Med Chem 38:735-738, 1995.
seed extract is currently used in Germany for the treatment of BPH.
Animal studies have confirmed its usefulness in the treatment of BPH
. Studies on the effects of pumpkin seed oil in combination with Saw
palmetto have been conducted, but no studies determining the effects of
pumpkin seed oil alone on BPH have been conducted in men.
(related to pumpkin seed extract):
Zhang X, Ouyang JZ, Zhang YS, Tayalla B, Zhou XC, Zhou SW. Effect of the
extracts of pumpkin seeds on the urodynamic of rabbits: an experimental
study. J Tongji Med Univ, 14(4):235-238, 1994.
lycopene has nothing to do with promoting hair growth, it has been
included in Natrecia. Many men will use Natrecia for prostate health (as
well as for hair health). Lycopene is a powerful anti-carcinogen.
is a pigmented substance found in tomatoes and other fruits and
vegetables. Its antioxidant effects may be protective against prostate
cancer. As a carotenoid, it has many vital health-promoting properties.
The carotenoids include beta-carotene, alpha-carotene, lutein, and beta-cryptoxanthin.
Among the common carotenoids, lycopene is the most efficient
free-radical scavenger [1,2]. This property will be discussed in greater
detail shortly. In addition, it is the predominant carotenoid found in
plasma and in the prostate gland [3,4,5,6].
a recent article published by the Journal of the National Cancer
Institute, lycopene was shown to be the only carotenoid to significantly
lower the risk of prostate cancer . In the study, the primary sources
of lycopene were tomato-based. Another beneficial source of lycopene is
strawberries. The lycopene in tomato sauce, however, was most effective.
The higher the intake of cooked tomato products, the lower the prostate
cancer rate. This is probably because tomato sauce is prepared by
cooking ripe tomatoes in an oil-based medium. This causes lycopene to be
placed in a "micellar" suspension (i.e., within oily droplets)
that is easily absorbed by the body. This is important because lycopene
is highly lipophilic (fat-soluble) and its intestinal absorption is
dependent on this "micellar" suspension. This preparation has
been shown to enhance the absorption of lycopene . This same study
revealed a two to threefold increase in plasma concentrations of
lycopene after ingestion of tomato sauce. In fact, in the study
mentioned above, ingestion of tomato sauce was the major predictor of
plasma lycopene levels .
studies have shown an inverse relationship between lycopene ingestion
and prostate cancer [9,10]. (“Inverse” means: as one factor is
increased, another factor decreases.) Lycopene probably protects against
prostate cancer by inhibiting the oxidation caused by free radical
production. Free radicals are formed in our bodies when certain fat
molecules react with oxygen. Free radical formation has been associated
with arthritis, hardening of the arteries, and the development of
cancer. Because it is an effective antioxidant, lycopene is thought to
exert protective effects against prostate cancer. It also happens to be
the most abundant carotenoid in the prostate and is twice as effective
as beta-carotene. Lycopene ingestion has also been shown to lower the
risk of digestive tract cancers.
(related to lycopene):
Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological
carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274:
Conn PF, Schlach W, Truscott TG. The singlet oxygen and carotenoid
interaction. J Photochem Photobiol 1991; 11:41-7.
Kaplan LA, Stein Ea, Willett Wc, et al. Reference ranges of retinol,
tocopherols, lycopene and alpha- and beta-carotene in plasma by
simultaneous high-performance liquid chromatographic analysis. Clin
Physiol Biochem 1987; 5:297-304.
Ascherio A, Stampfer MJ, Colditz Ga, et al. Correlations of vitamin A
and E intakes with the plasma concentrations of carotenoids and
tocopherols among American men and women. J Nutr 1992;122:1792-801.
Stryker WS, Kaplan LA, Stein Ea, et al. The relation of diet, cigarette
smoking and alcohol consumption to plasma beta-carotene and alpha-tocopherols
in diet and plasma. Am J Epidemiol 1987;45:764-9.
Kaplan LA, Lau JM, Stein EA, et al. Carotenoid composition,
concentrations, and relationships in various human organs. Clin Physiol
Giovannucci E, Ascherio A, Rimm E, et al. Intake of Carotenoids and
Retinol in Relation to Risk of Prostate Cancer. J Natl Cancer Inst 1995;
Stahl W, Sies H. Uptake of lycopene and its geometrical isomers is
greater from heat- processed than from unprocessed tomato juice in
humans. J Nutr 1992; 122:2161-6.
Mills PK, Beeson WL, Phillips RL, et al. Cohort study of diet,
lifestyle, and prostate cancer in Adventist men. Cancer 1989;64:598-604.
Hsing AW, Comstock GW, Abbey H, et al. Serologic precursors of cancer. J
Natl Cancer Inst 1990;82:941-6.
have always known that diet is important. As discussed in the book,
Conquering Hair Loss, the consumption of animal fat leads to the
production of DHT. Well, guess what? If DHT is bad for prostate health,
then animal fat cannot be good for the prostate either. Exercise has
also been shown to reduce the risk of prostate cancer.
recent study from the Northwestern University School of Medicine has
demonstrated that men who consumed red meat at least five times weekly
had a 2.5 times higher chance of suffering from prostate cancer than men
who consumed red meat less than once weekly . Another study,
performed at Stanford University School of Medicine, concluded that men
who consume large amounts of saturated fats (more than 45 grams per day)
have a higher risk of developing prostate cancer than men consuming
smaller quantities (less than 22 grams per day) . This study also
showed that saturated fats obtained from both red meats and dairy
products were equally dangerous.
(related to fat consumption):
Gann, Peter H., et al. Prospective study of plasma fatty acids and risk
of prostate cancer. Journal of the National Cancer Institute, Vol. 86,
No.4, February 16, 1994, pp. 281-286.
Whittemore, Alice S., et al. Prostate cancer in relation to diet,
physical activity, and body size in Blacks, Whites and Asians in the
United States and Canada. Journal of the National Cancer Institute, Vol.
87, No. 9, May 3, 1995, pp.652-61.
recent report indicates that men with higher cardiorespiratory fitness
levels are four times less likely to develop prostate cancer than men
with low cardiorespiratory fitness levels . This same study also
states that men who are physically active have a lower incidence of
prostate cancer than men who are less active. These researchers believe
exercise decreases the levels of testosterone, which is a hormone
associated with prostate cancer.
(related to exercise and prostate cancer):
Oliveria, Susan A., et al. The association between cardiorespiratory
fitness and prostate cancer. Medicine and Science in Sports and
Exercise, Vol. 28, No. 1, January 1996, 97-104.
We have discussed many natural agents that reduce the effects of DHT on the prostate. Natrecia is a completely natural, vitamin, mineral, and herbal supplement specifically developed for combating the effects of androgenic alopecia (i.e., male-pattern baldness). Its formulation is based on a great deal of research that firmly establishes that these natural agents can combat the effects of dihydrotestosterone (DHT) in the treatment of benign prostatic hyperplasia (BPH). Because many studies have shown that the same culprit, DHT, is responsible for both male-pattern baldness and benign prostate enlargement, it is reasonable to expect that Natrecia will be useful for both conditions. And, these natural agents produce virtually no side effects.